This paper attempts to define a hierarchy to be followed in order for a practical approach to determining the origins and implications of the pathogenic forms that are appearing to cross airborne and biological lines, and have been observed in airborne, skin, dental and blood samples. This hierarchy can be described as follows: 1) Conventional scientific expertise should be applied to the problem of identification of these two forms. 2) Modified or unconventional biological forms or interaction are then reasonable to consider. 3) Artificial, exotic and unfamiliar technologies could be explored for any relationship to unexplainable events or circumstances. There are two forms that require immediate identification as to their physical nature, function and purpose. The first of these is a sub-micron repeating filament that is enclosed within a larger bounding filament. The sub-micron filaments can only be seen with fairly advanced microscopy; the bounding filament is visible to the naked eye in many cases. The second form is a circular, spherical or oblate structure that also is measuring at the micron to sub-micron level.